Pergolide is a semisynthetic, clavine ergot derivative dopamine agonist. In contrast to bromocriptine, it is a strong D2 receptor agonist and a weak Dl receptor agonist. Pergolide is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.
In one study, Pergolide permitted a mean levodopa dose reduction of 24.7%, motor function improved by 35% in pergolide-treated patients and 'off' time decreased by 32%.
Important Information About Pergolide
Do Not Take Pergolide If
Seek emergency medical attention if you have taken an overdose.
Symptoms of a pergolide overdose include nausea, vomiting, weakness, dizziness, fainting, agitation, confusion, hallucinations, muscle twitching, uncontrollable movements, a tingling sensation, and irregular heartbeats.
Avoid while taking pergolide
Use caution when driving, operating machinery, or performing other hazardous activities. pergolide may cause low blood pressure (leading to dizziness and other symptoms), especially when you rise from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.
Side effects of pergolide
Potential side effects include nausea, vomiting, orthostatic hypotension, cognitive dysfunction, increased liver enzymes, erythromelalgia, and peripheral edema.
Stop taking pergolide and seek emergency medical attention if you experience:
Continue to take pergolide and talk to your doctor if you experience the following less serious, but more common, side reactions:
Before taking pergolide, tell your doctor if you are taking any of the following medicines:
The medicines listed above may decrease the effects of pergolide. Your doctor may want to adjust your pergolide dosage if you are taking any of these medicines.
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