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Parkinson's Disease HOL-emblem1-web.GIF (3556 bytes)

Pergolide

BRAND: Permax

Pergolide is a semisynthetic, clavine ergot derivative dopamine agonist. In contrast to bromocriptine, it is a strong D2 receptor agonist and a weak Dl receptor agonist. Pergolide is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.

In one study, Pergolide permitted a mean levodopa dose reduction of 24.7%, motor function improved by 35% in pergolide-treated patients and 'off' time decreased by 32%.

Important Information About Pergolide
bulletUse caution when driving, operating machinery, or performing other hazardous activities. pergolide may cause low blood pressure (leading to dizziness and other symptoms), especially when you rise from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.
bulletHallucinations may occur if pergolide is taken with levodopa. Call your doctor if you experience hallucinations.

Do Not Take Pergolide If
bulletYou may require a lower dose or special monitoring during your therapy with pergolide if you have any type of heart disease, such as irregular heartbeats or a history of a heart attack.
bulletPergolide is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take pergolide without first talking to your doctor if you are pregnant.
bulletIt is not known whether pergolide passes into breast milk. Do not take pergolide without first talking to your doctor if you are breast-feeding a baby.

Drug overdose

Seek emergency medical attention if you have taken an overdose.

Symptoms of a pergolide overdose include nausea, vomiting, weakness, dizziness, fainting, agitation, confusion, hallucinations, muscle twitching, uncontrollable movements, a tingling sensation, and irregular heartbeats.

Avoid while taking pergolide

Use caution when driving, operating machinery, or performing other hazardous activities. pergolide may cause low blood pressure (leading to dizziness and other symptoms), especially when you rise from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.

Side effects of pergolide

Potential side effects include nausea, vomiting, orthostatic hypotension, cognitive dysfunction, increased liver enzymes, erythromelalgia, and peripheral edema.

Stop taking pergolide and seek emergency medical attention if you experience:
bulletAn allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
bulletNotify your doctor immediately if you experience irregular heartbeats, hallucinations, or dizziness (especially when rising from a sitting or lying position). Your doctor may want to discontinue this medication or lower your dosage.

Continue to take pergolide and talk to your doctor if you experience the following less serious, but more common, side reactions:
bulletMild nausea, vomiting, upset stomach, or decreased appetite
bulletDiarrhea or constipation
bulletDry mouth
bulletDrowsiness
bulletInsomnia
bulletAgitation or anxiety.

Drug Interaction

Before taking pergolide, tell your doctor if you are taking any of the following medicines:
bulletA phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and Others
bulletHaloperidol (Haldol)
bulletThiothixene (Navane)
bulletMetoclopramide (Reglan).

The medicines listed above may decrease the effects of pergolide. Your doctor may want to adjust your pergolide dosage if you are taking any of these medicines.

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