Name: Pygeum africanum
Chemical analysis and pharmacological studies indicate that the lipophilic extract of pygeum bark has three categories of active constituents. The phytosterols, including beta-sitosterol, have anti-inflammatory effects by interfering with the formation of pro-inflammatory prostaglandins that tend to accumulate in the prostate of men with benign prostatic hyperplasia (BPH). The pentacyclic terpenes have an anti-edema or decongesting effect. The last group are the ferulic esters. These constituents reduce levels of the hormone prolactin and also block cholesterol in the prostate. Prolactin increases uptake of testosterone in the prostate, and cholesterol increases binding sites for testosterone and its more active form dihydrotestosterone.
The powdered bark was used as a tea for relief of urinary disorders. European scientists began laboratory investigations into the active constituents in the bark. This led to the development of the modern lipophilic (fat soluble) extract used today.
• benign prostatic hyperplasia
Pygeum is an evergreen tree found in the higher elevations of central and southern Africa. The bark is used.
The accepted form of pygeum used in Europe for treatment of BPH is a lipophilic extract standardized to 13% total sterols (typically calculated as beta-sitosterol). The recommended dose is 50-100 mg two times per day. Pygeum should be monitored over at least a six- to nine-month period to determine efficacy. As is the case with all BPH treatments, close medical supervision is of the utmost importance.
Side effects to the lipophilic extract of pygeum are rare. In clinical studies, there were very rare reports of mild gastrointestinal irritation in some patients.
No other information available. Some herbs are known to react with your medication. Please consult your physician before starting on any herb.