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INTERACTIONS OF GRAPEFRUIT WITH MEDICATIONS

References

Bailey, D.G., Malcolm, J., Arnold, O. and Spence, J.D. Grapefruit Juice-Drug Interactions, Br. J. Clin. Pharmacol. 1998; 46: p. 101-110.

Nemeroff, C.B., De Vane, L. C., Pollock, B.G. Newer Antidepressants and the Cytochrome P450 System, Am. J. Psychiatry 1996; 153:3: P. 311-320.

Dean Elbe, B.Sc. (Pharm.) Grapefruit Juice-Drug Interaction Web Site: <http://www.powernetdesign.com/grapefruit>

Joseph E. Huggins, M.D. Diagnostic & Treatment (D&T)

Ameer B, Weintraub RA. Drug Interactions with Grapefruit Juice. Clin Pharmacokinet 33: 103-121, 1997.

Chan WK, Nguyen LT, Miller VP, Harriz RZ. Mechanism-Based Inactivation of Human Cytochrome P450 3A4 by Grapefruit Juice and Red Wine. Life Sciences 62: 135-142, 1998. Jorquera F, Culebras JM, Gonzalez-Gallergo J. Nutrition 12: 442-447, 1996. Influence of Nutrition on Liver Oxidative Metabolism. (review)

Edwards DJ, Bellevue FH, Woster PM. Identification of 6',7'-dihydroxybergamottin, a Cytochrome P450 Inhibitor, in Grapefruit Juice. Drug Metabolism and Disposition 24: 1287-1290, 1996.

Fuhr U. Maier A, Keller A, Steinijans VW, Sauter R, Staib AH. Lacking Effect of Grapefruit Juice on Theophylline Pharmacokinetics. International Journal of Clinical Pharmacology and Therpeutics 33: 311-314, 1995.

Fukuda K, Ohta T, Yamazoe Y. Grapefruit Component Interacting with Rat and Human P450 CYP3A: Possible Involvement of Non-Flavonoid Components in Drug Interaction. Biol Pharm Bull 20: 560-564, 1997.

Feldman EB. How Grapefruit Juice Potentiates Drug Bioavailability. Nutr Rev 55: 398-400. (review)

Benton RE, Honig PK, Zamani K et al. Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram.  Clin Pharmacol Ther 1996, 59: 383-8.

Hollander AA, Rooij J, Lentjes EG, Arbouw F, vanBree JB, Schoemaker RC, vanEs LA, vanderWoude FJ, Cohen AF. the effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients. Clin Pharmacol Ther 56: 318-324, 1995.

Kall MA, Clausen J. Dietary effect on mixed function P450 1A2 activity assayed by estimation of caffeine metabolism in man. Hum Exp Toxicol 1995 oct;(10): 801-7.

Kall MA, Vang O, Clausen. Effects of dietary broccoli on human in vivo drug metabolizing enzymes: caffeine, oestrone and chloroxazone metabolism. Carcinogenesis 1996; 17:(4):793-799.

Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guy W, Watkins PB. Grapefruit Juice Increases Felodipine Oral Availability in Humans by Decreasing Intestinal CYP3A Protein Expression. J Clin Invest 99: 2545-2553, 1997.

Walter-Sack I, Klotz U. Influence of Diet and Nutritional Status on Drug Metabolism. Clin Pharmacokinet 31: 47-64, 1996.

Kantola T et al. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998; 63: 397-402.

Lilja, JJ, Kivisto KT, Neovonen PJ. Grapefruit juice-simvastatin interactions: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors.  Clin Pharmacol Ther 1998; 64: 477-83.

Lilja JJ, Kivisto KT, Neuvonen PJ.  Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin.  Clin Pharmacol Ther 1999; 66: 118-27.

Hukkinen SK, Varhe A, Olkkola KT et al.  Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.  Clin Pharmacol Ther 1995; 58: 127-31.

Ozdemir M, Aktan Y, Boydag BSInteraction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet 1998 Jan-Mar;23(1):55-9.

Bailey DG, Spence, JD, Munoz C et al. Interaction of citrus juices with felodipine and nifedipine. Lancet, 1991; 337: 268-9.

Josefsson M, Zackrisson A.-L., Ahlner J.  Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers.  Eur J Clin Pharmacol 1996, 51: 189-93.

Bailey DG, Arnold JMO, Strong HA et al.  Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics.   Clin Pharmacol Ther; 54: 589-94.

Sigusch H, Henscel L, Kraul H et al.  Lack of effect of grapefruit juice on diltiazem bioavialablility in normal subjects.  Pharmazie 1994: 49: 675-679.

Hollander AAMJ, van Rooij J, Lentjes EGWM et al.  The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients.  Clin Pharmacol Ther 1995; 57: 318-24.

Yee GC, Stanley DL, Pessa LJ et al.   Effect of grapefruit juice on blood cyclosporin concentration.  Lancet 1995; 345: 955-6.

Ducharme MP, Provenzano R, Dehoorne-Smith M et al.  Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br J Clin Pharmacol 1993: 36: 457-9.

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