Home
Search Holisticonline
Grandmas Remedies
Quality vitamins,  natural remedies
Specialgifts.com
Big savings on gemstones, jewelry and gifts.
Alternative Medicine

Stress Management

Conditions/ Treatments
Preferred Providers
Holistic Living
Alternative Therapies
Acupuncture
Aromatherapy
Ayurveda
Biofeedback
Chelation Therapy
Herbal Medicine
Homeopathy
Humor Therapy
Hydrotherapy
Imagery
Light Therapy
Massage
Meditation
NLP
Nutrition
Prayer/ Spiritual
Reiki
Shiatsu
Yoga
FAQ (Health)
Feedback
Register
Media
 

Holisticonline.com

INTERACTIONS OF GRAPEFRUIT WITH MEDICATIONS

Interaction of Grapefruit Juice with Antihistamines

The most significant interaction of grapefruit juice occurred with anithistamines. Do not take grapefruit juice if you are taking terfenadine (seldane) or astemizole (Hismanal) due to the possibility of fatal cardiac arrhythmias. Other non-sedating antihistamines are available which do not appear to interact with grapefruit juice. (e.g., loratidine (Claritin) cetirizine (Reactine) or fexofenadine (Allegra). 

In Australia, it is routine practice to add auxiliary labelling to prescriptions for terfenadine warning of grapefruit-juice drug interactions. In the United States, the manufacturer of terfenadine has changed its prescribing information to indicate that GJ should not be taken with terfenadine.

The most significant documented grapefruit juice drug interaction occurred with terfenadine (Seldane). A previously healthy 29-year old male used terfenadine twice daily for one year to treat allergic rhinitis. The patient drank grapefruit juice two to three times weekly. On the day of his death, he consumed two glasses of juice, took his terfenadine dose, and proceeded to mow the lawn. He became ill, collapsed and died. Post-mortem terfenadine and terfenadine metabolite plasma levels were reported as 35 ng/mL and 130 ng/mL respectively. (In normal cases, the plasma concentration is not detectable.) These levels are within range of previously noted arrhythmogenic levels of terfenadine. The individual had both cardiomegaly and hepatomegaly, but no evidence of impaired hepatic function.

To study the effect of grapefruit juice on terfenadine 12 healthy subjects were given terfenadine 60 mg with either water or grapefruit juice, co-administered with terfenadine or delayed by 2 hours. 

Results:

bulletNone of the 12 had quantifiable levels when the drug was given with water. 
bulletOf subjects who took terfenadine co-administered with grapefruit juice, 100% had quantifiable terfenadine levels.
bulletOf subjects who delayed grapefruit juice ingestion by 2 hours, 33% had quantifiable levels. 
bulletIn the group of subjects which co-administered grapefruit juice and terfenadine, a significant mean prolongation in the QT interval measured by electrocardiogram was demonstrated. 

Next Topic: Interaction of Grapefruit Juice with Cholesterol Lowering Drugs

[Look For Another Herb][HolisticOnLine Home]

HolisticOnLine is developed and maintained by International Cyber Business Services, Inc.
Send mail to: info@holisticonline.com with questions or comments about this web site.
Copyright 1998-2000 International Cyber Business Services, Inc. Terms of Use All Rights Reserved.